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With Dr. John Watson about to marry and end their partnership, a disconsolate Sherlock Holmes occupies his time investigating the schemes of his archenemy, Professor James Moriarty. However, when Moriarty warns that he considers the Watsons a legitimate target for his retaliation against the detective, Holmes must save them and get John involved in one last case. To do so, they join the Roma lady Madam Simza Heron's quest to find her missing brother, Renee, who may be the key to defeating Moriarty. Together, the trio find themselves involved in a dangerous international conspiracy led by the Napoleon of Crime in which the fate of all of Europe hangs in the balance.
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| Robert Downey Jr. |
(Sherlock Holmes) |
| Rachel McAdams |
(Irene Adler) |
| Noomi Rapace |
(Sim) |
| Jared Harris |
(Professor Moriarty) |
| Jude Law |
(Dr. John Watson) |
| Stephen Fry |
(Mycroft Holmes) |
| Kelly Reilly |
(Mary Morstan) |
| Geraldine James |
(Mrs. Hudson) |
| Eddie Marsan |
(Inspector Lestrade) |
| William Houston |
(Clarky) |
| Gabrielle Scharnitzky |
(Frau von Hoffmannstahl) |
| Gilles Lellouche |
() |
| Affif Ben Badra |
() |
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| Christian Wolf-La'Moy |
(Rake in Cockpit Fight) |
| Paul Anderson |
(Moran) |
| Dominic Kinnaird |
(Moriarty's Guard) |
| Carsten Hayes |
(Photographer) |
| Thorston Manderlay |
(Alfred Meinhard) |
| Roman Jankovic |
(German guard) |
| Ray Donn |
(Gentleman (uncredited)) |
| Ninette Finch |
(Train Passenger (uncredited)) |
| Jefferson King |
(Shush Club Rich Punter (uncredited)) |
| David Lyddon |
(Vilian (uncredited)) |
| Dean Mitchell |
(Searcher (uncredited)) |
| Lucy Scarfe |
(Paris Middle-Class Woman (uncredited)) |
| Paul Warren |
(Gypsy (uncredited)) |
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